Doxil® + Melphalan + Velcade (DMV) in Relapsed/Refractory Multiple Myeloma

Dose Level 1: Doxil 10 mg/m2, Melphalan 5 mg/m2, Velcade 0.7 mg/m2 Dose Level 2: Doxil 10 mg/m2, Melphalan 10 mg/m2, Velcade 0.7 mg/m2 Dose Level 3: Doxil 20 mg/m2, Melphalan 10 mg/m2, Velcade 0.7 mg/m2 Dose Level 4: Doxil 20 mg/m2, Melphalan 10 mg/m2, Velcade 1.0 mg/m2 Adjunctive therapy with a bisphosphonate, either pamidronate or zoledronic acid, will be given monthly. Dose Escalation Schedule: Dose escalation will occur only after patients have completed at least two cycles at a given dose level. 1. If 0/3 experience DLT (as defined in attachment Section 6.0), the next three patients will be escalated by one dose level. 2. If 1/3 experience DLT, 3 additional patients enrolled at this dose level. * If 0, 1, or 2 of these additional patients experience DLT (i.e. total 3/6), the dose will be escalated. * If 3/3 experience DLT (i.e. total 4/6) then the next lower dose will be considered the MTD.. 3. If 2/3 experience DLT, 3 additional patients enrolled at this dose level. * If 0 or 1 of these additional patients experience DLT (i.e. total 3/6), the dose will be escalated. * If 2 or more/3 experience DLT (i.e. total more than 3/6) then the next lower dose level is MTD