Age

18–55

Sex

ALL

Healthy volunteers

Not accepted

age 18 to 55
informed written consent
multiple sclerosis (Mc Donald criteria, relapsing-remitting
EDSS before relapse : 0 to 5
relapse : increase of 1 point or more for 1 or more functional systems of Kurtzke, with SF score most affected \> 1 for all functions except for sensory (\> 2); duration of symptoms \> 24 h

fever
previous relapse, and/or corticosteroid treatment \< 1 month before present relapse
first symptoms of the present relapse appeared \> 15 days before inclusion
under mitoxantrone of cyclophosphamid or natalizumab treatment
diabetes
infection not under control
liver or kidney failure
psychiatric symptoms not under control
pregnancy
hypersensibility to methylprednisolone

Efficacy and Safety of Methylprednisolone Per os Versus IV for the Treatment of Multiple Sclerosis (MS) Relapses