Study of Live Attenuated ChimeriVax™-Japanese Encephalitis Vaccine

Exclusion Criteria

• •A history of vaccination or infection to Japanese encephalitis (JE) or yellow fever (YF) or other flaviviruses (including Japanese encephalitis, tick-borne encephalitis, St Louis encephalitis, West Nile virus, dengue fever, Murray Valley encephalitis). Previous vaccination will be determined by history (interview of subject).
• •Previous or current military service.
• •History of residence in or travel to flavivirus endemic areas in the tropics (Cape York region of Northern Queensland, India, Southeast Asia, Central America, Caribbean or South America) for periods of 4 weeks or more.
• •Known or suspected immunodeficiency (e.g., human immunodeficiency virus \[HIV\] infection, primary immunodeficiency disorder, leukemia, lymphoma), use of immunosuppressive or antineoplastic drugs (corticosteroids \> 10 mg prednisone, or equivalent, in the last three months or during the trial (up to Day 30).
• •History of thymoma, thymic surgery (removal) or myasthenia gravis.
• •Clinically significant abnormalities on laboratory assessment (i.e., meeting the mild, moderate or severe criteria described in the toxicity gradings for laboratory values).
• •Anaphylaxis or other serious adverse reactions characterised by urticaria or angioedema to foods, hymenoptera (bee family) stings, or drugs (including vaccines).
• •Transfusion of blood or treatment with any blood product, including intramuscular or intravenous serum globulin within six months of the Screening Visit or up to Day 30.
• •Administration of another vaccine or antiviral within 30 days preceding the screening visit or up to Day 30 (these subjects will be rescheduled for vaccination at a later date).
• •Physical examination indicating any clinically significant medical condition.
• •Body temperature \> 38.1°C (100.6°F) or acute illness within 3 days prior to inoculation (participant may be rescheduled).
• •Intention to travel out of the area prior to the study visit on Day 30.
• •Seropositive to hepatitis C virus or HIV or positive for Hepatitis B Surface Antigen.
• •Lactation or intended pregnancy in female subjects.
• •Excessive alcohol consumption, drug abuse, significant psychiatric illness.
• •A known or suspected physiological or structural condition that compromises the integrity of the blood-brain barrier (e.g., significant hypertensive cerebrovascular disease, trauma, ischaemia, infection, inflammation of the brain).
• •Intention to increase normal exercise routine, participate in contact sports or strenuous weight lifting or to initiate vigorous exercise from Screening until after Day 30.