NOX-E36 First-in-Human (FIH) Study

Exclusion Criteria

• •Male and female subjects who are not or whose partners are not willing to use appropriate contraception methods
• •Intake of any prescribed systemic or topical medication within 14 days prior to dosing
• •Intake of any non-prescribed systemic or topical medication (including herbal remedies) within 7 days prior to dosing (with the exception of vitamin/mineral supplements)
• •Supine blood pressure and supine pulse rate higher than 140/90 mmHg and 100 beats per minute (bpm), respectively, or lower than 90/50 mmHg and 40 bpm, respectively, as confirmed by a repeat assessment
• •History of any clinically significant neurological, dermatological, gastrointestinal, renal, hepatic, cardiovascular, psychiatric, respiratory, metabolic, endocrine, haematological or other major disorders