Saves the questions and what to expect into your notes, next to the visit they belong to.
Keep this study
Lead
Pfizer
Age
18–any
Sex
ALL
Healthy volunteers
Not accepted
You may be eligible if
Subject must have a diagnosis of rheumatoid arthritis based on the American College of Rheumatology Association
The subject has active disease at both Screening and Baseline, as defined:
* ≥4 joints tender or painful on motion, AND
* ≥4 joints swollen;
The subject must have at least one knee, one elbow, one wrist or two metacarpophalangeal joints with active synovitis suitable for biopsy by the shaver technique
You may not be if
No arthroscopy should have been performed in the past 3 months in the same joint that is to be biopsied in this study.
No intra-articular steroids should have been injected in the joint to be biopsied in this study in the previous 3 months.
Subjects with evidence of hematopoietic disorders or evidence of hemoglobin levels \< 9.0 gm/dL or hematocrit \< 30 % at screening visit or within the 3 months prior to baseline synovial biopsy.
An absolute white blood cell (WBC) count of \< 3.0 x 109/L (\<3000/mm3) or absolute neutrophil count of \<1.2 X 109/L (\<1200/mm3) at screening visit or within the 3 months prior to baseline synovial biopsy.
Thrombocytopenia, as defined by a platelet count \<100 x 109/L (\< 100,000/mm3) at screening visit or within the 3 months prior to baseline synovial biopsy.
Estimated GFR less than 40 ml/min based on Cockcroft Gault calculation .
