Saves the questions and what to expect into your notes, next to the visit they belong to.
Keep this study
Lead
Queen's University
With
Canadian Lung Association
Age
40–any
Sex
ALL
Healthy volunteers
Accepted
You may be eligible if
Post-bronchodilator forced expiratory volume in 1 sec (FEV1) ≥ 80%predicted and a FEV1/forced vital capacity (FVC) ratio \< 0.70;
Clinically stable as defined by no changes in medication dosage or frequency of administration with no exacerbations or hospitalizations in the preceding 6 weeks;
A cigarette smoking history ≥ 20 pack-yrs;
Body mass index between 18.5 and 30 kg/m2;
Able to perform all study procedures and provide informed consent.
You may not be if
A diffusing capacity of the lung for carbon monoxide (DLCO) \< 40 %predicted;
Presence of active cardiopulmonary disease (or comorbidities) other than COPD that could contribute to dyspnea and exercise limitation;
Clinical diagnosis of sleep disordered breathing;
History or clinical evidence of asthma;
Presence of important contraindications to clinical exercise testing, including inability to exercise because of neuromuscular or musculoskeletal disease(s);
Use of daytime oxygen or exercise-induced arterial oxygen desaturation to \<80% on room air.
Clareo Health | Pathophysiological Mechanisms of Dyspnea and Activity-limitation in Mild Chronic Obstructive Pulmonary Disease (COPD)
