Boron Neutron Capture Therapy, Radiation Therapy, and Temozolomide in Treating Patients With Newly Diagnosed Glioblastoma Multiforme

You may be eligible if

• DISEASE CHARACTERISTICS:
• Histologically confirmed glioblastoma multiforme
• * Newly diagnosed disease
• Tumor located at a supratentorial hemisphere
• * Deepest part of tumor \< 6 cm from the scalp
• * Bottom of the tumor \> 6 cm from the scalp allowed provided air instillation into tumor-removed cavity is possible
• No cerebrospinal fluid dissemination
• PATIENT CHARACTERISTICS:
• Karnofsky performance status 70-100%
• Life expectancy \> 3 months
• Leukocyte count ≥ 3,000/μL
• Platelet count ≥ 10.0 × 10\^4/μL
• Hemoglobin ≥ 8.0 g/dL
• Serum creatinine ≤ 1.5 mg/dL
• ALT and AST ≤ 100 IU/L
• No phenylketonuria
• Not pregnant or nursing
• No NYHA class III-IV heart failure
• No patient whose participation in the present study is considered inappropriate by a Principal Investigator or Clinical Investigator
• PRIOR CONCURRENT THERAPY:
• No prior chemotherapy or radiotherapy