Fatigue in Breast Cancer Survivors

OBJECTIVES: * To investigate the relationship between fatigue severity; protein biomarkers; and measures of activity, sleep, mood, and cognition in breast cancer survivors. * To identify and quantify serum biomarkers and underlying biological pathways unique to cancer-related fatigue syndrome in these survivors. * To map changes over time in order to explore the inter-relationships between these variables. OUTLINE: Participants undergo fatigue assessment by the Diagnostic Interview for Cancer Related Fatigue and the FACT-Fatigue questionnaire; psychological symptoms assessment by the Structured Clinical Interview for DSM-IV, Hospital Anxiety and Depression Scale, and the Insomnia Severity Index questionnaires; and quality of life assessment by the EORTC-QLQc30 and EORTC-QLQ-BR23 questionnaires twice approximately 3 months apart. Participants also undergo activity level, circadian rhythm, and sleep measurements by the Micro-mini® Motionlogger actigraphy and measurement of cognitive disturbances by the Cantabeclipse™ technology. Participants undergo blood sample collection for protein analysis by 2D gel electrophoresis and mass spectrometry.