Mechanism of Insulin-Resistant in Lean Non-Diabetics

Exclusion Criteria

• •Diabetes, Cardiovascular disease, Pregnant or lactating females,BMI \>27
• •Medications that may interfere with carbohydrate metabolism - glucocorticoids, adrenergic agonists, ACE inhibitors, alpha blockers, diuretics, beta blockers, oral contraceptives, HMG CoA reductase inhibitors
• •History of epilepsy, cancer, hepatitis, active infection, active Graves' disease, cystic fibrosis, sickle cell anemia, peripheral vascular disease, cerebrovascular disease, asthma
• •Any medical condition that in the opinion of the investigator will interfere with safe completion of the trial
• •Inability to give informed consent
• •Prior participation in a clinical trial that could potentially alter insulin sensitivity: e.g., use of new insulin sensitizers
• •HIV seropositive
• •Anemia (Hgb \< 12 g/dl)