Saves the questions and what to expect into your notes, next to the visit they belong to.
Keep this study
Lead
Massachusetts General Hospital
With
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Age
10–18
Sex
ALL
Healthy volunteers
Not accepted
You may be eligible if
Girls and boys ages 10 to 18 years old
Body mass index more than 95th percentile for age and gender
Insulin resistance based on:
* Fasting parameters: Fasting insulin level, HOMA IR
* Oral glucose tolerance testing
Mitochondrial function \> 1 median for normal based on control cohort
You may not be if
Underlying medical problem with potential to affect growth, pubertal development or glucose homeostasis
Chronic medical therapy with glucocorticoids, growth hormone, estrogen, progesterone, testosterone, or other medications with the potential to alter growth, pubertal development or glucose homeostasis within the proceeding 6 months
Personal history of DM
Inability to have MRI scan performed due to metal prosthesis or implant
