Saves the questions and what to expect into your notes, next to the visit they belong to.
Keep this study
Lead
Revotar Biopharmaceuticals AG
Age
18–65
Sex
ALL
Healthy volunteers
Accepted
You may be eligible if
Able to produce sputum with normal sputum neutrophil levels at screening (\< 65% of non-epithelial cells).
Ozone responsive, defined as ≥ 20% relative increase in sputum neutrophils cell count after 3 h ozone challenge.
At screening FEV1 at least 80% of predicted.
You may not be if
Smokers (use of tobacco products in the previous 3 months). Urine cotinine levels will be measured during screening for all subjects. Smokers will be defined as any subject who reports of a recent tobacco use and/or who has a urine cotinine ≥ 500 ng/mL.
Significant illness within two weeks prior to dosing (e.g., infection).
Recent (within the last three years) and/or recurrent history of acute or chronic bronchospastic disease (including asthma and chronic obstructive pulmonary disease, treated or not treated).
Clareo Health | Study to Evaluate the Effect of Bimosiamose on Ozone Induced Sputum Neutrophilia
