History of Type 1 diabetes mellitus, diabetic ketoacidosis, hyperosmolar nonketotic syndrome, incontinence, or nocturia

Use of any blood glucose lowering agent other than metformin

Prior exposure to insulin, thiazide, or loop diuretics within 4 weeks prior to screening

Laboratory or electrocardiogram abnormalities deemed significant by the Sponsor or the Investigator

Positive test result for glutamic acid decarboxylase (GAD) antibody

Surgery within 6 months of screening

Exposure to any investigational agent or participation in any investigational trial within 30 days prior to Day 1

Hypersensitivity to an SGLT2 inhibitor

History of drug or alcohol abuse within the last 12 months

Study of LX4211 in Subjects With Type 2 Diabetes Mellitus