Saves the questions and what to expect into your notes, next to the visit they belong to.
Keep this study
Lead
Array Biopharma, now a wholly owned subsidiary of Pfizer
Age
18–any
Sex
ALL
Healthy volunteers
Not accepted
You may be eligible if
A histologically or cytologically confirmed diagnosis of colorectal adenocarcinoma which is metastatic (measurable disease).
Documented KRAS- or BRAF- tumor mutation.
Previously treated with or unsuitable for treatment with 5-Fluorouracil (5-FU), oxaliplatin, irinotecan and, if available, bevacizumab.
Eastern Cooperative Oncology Group (ECOG) performance status of 0, 1 or 2.
Additional criteria exist.
You may not be if
Uncontrolled or symptomatic brain metastases (if the patient has brain metastases and is on steroids, the steroid dose must have been stable for at least 30 days).
History of central serous retinopathy, retinopathy visible at baseline that would be considered a risk factor for central serous retinopathy or retinal vein occlusion.
Concomitant malignancies or previous malignancies with less than a 2-year disease free interval at the time of enrollment; patients with adequately resected basal or squamous cell carcinoma of the skin, carcinoma in situ of the cervix, or stage A low grade prostate cancer may enroll irrespective of the time of diagnosis.
Prior treatment with a MEK inhibitor.
Treatment with prior chemotherapy, anticancer immunotherapy, monoclonal antibodies or other protein or peptide therapeutics within 21 days of the first dose of study drug.
Treatment with a small molecule targeted agent or anticancer hormonal therapy within 14 days of the first dose of study drug.
Treatment with prior radiotherapy within 28 days of initiating study drug (if the radiation portal covered ≤ 10% of the bone marrow reserve, the patient may be enrolled irrespective of the end date of radiotherapy).
Major surgery within 4 weeks or minor surgery within 7 days prior to the first dose of study drug.
Known positive serology for the human immunodeficiency virus (HIV), hepatitis C, and/or active hepatitis B.
Additional criteria exist.
Clareo Health | A Study of ARRY-438162 (MEK162) in Patients With Advanced Cancer
