Saves the questions and what to expect into your notes, next to the visit they belong to.
Keep this study
Lead
Dartmouth-Hitchcock Medical Center
Age
18–any
Sex
ALL
Healthy volunteers
Not accepted
You may be eligible if
All patients must have pathologic diagnosis of one of the following malignancies: Non-Hodgkin's Lymphoma, Hodgkin's Disease, Multiple Myeloma or other plasma cell dyscrasia (Waldenstrom, Amyloidosis), Leukemia (AML, ALL, CLL)
Prior Treatment: \> 2 weeks prior to initiation of therapy.
Performance Status: Karnofsky \> 70%
Age \>18
Life Expectancy \> 4 months
Bone Marrow: bone marrow biopsy and aspirate
Blood counts: The patient must have adequate bone marrow function, i.e. a total WBC of \> 2,000/ul, a Hgb of \> 7 mg/dl, and a platelet count of \> 50,000/ul, unless this abnormality is believed to be due to the underlying disease.
Pulmonary function tests: DLCO \> 55% predicted.
Cardiac: Left ventricular ejection fraction of \> 40% by radionuclide scan or echocardiography.
Liver function tests (bilirubin, alkaline phosphatase, and SGOT/SGPT) \< 3 x normal (unless believed to be elevated due to disease).
No significant co-morbid medical or psychiatric illness that would significantly compromise the patient's clinical care and chances of survival.
You may not be if
Medical, social, or psychological factors which would prevent the patient from receiving or cooperating with the full course of therapy.
Evidence on physical exam, LP, CT, or MRI scans of CNS involvement with malignancy.
Uncontrolled or severe cardiovascular disease, including recent (\< 6 months) myocardial infarction, congestive heart failure, angina (symptomatic despite optimal medical management), life-threatening arrhythmia, or hypertension or clinically significant obstructive/restrictive pulmonary disease.
Serology positive for HIV
History of seizures.
Concurrent or expected need for therapy with systemic corticosteroids (since systemic steroids may suppress the effects of IL-2).
Current and clinically significant pleural effusion, pericardial effusion, or ascites.
Positive pregnancy test or presence of lactation.
Uncontrolled active infection.
Documented hypersensitivity to any of the drugs used in the protocol.
No concomitant, ongoing malignancy that is life-threatening, based on PI's evaluation
Clareo Health | Immune Mobilization of Autologous Peripheral Blood Stem Cells Using Interleukin-2 and GM-CSF
