Post-operative or Early Salvage XRT and ADT for High Risk PCa

You may be eligible if

• DISEASE CHARACTERISTICS:
• Diagnosis of prostate cancer
• * Clinical stage cT1-2-3a, N0, M0 disease pre-operatively
• * Pre-operative PSA ≤ 5 x upper limit of normal
• Presenting the following conditions after radical prostatectomy:
• * Gleason sum 5-10
• * Pathologic stage pT2R1 (positive surgical margins with at least a tumor trans-section \> 2 mm) or pT3a-b (irrespective of margin status)
• * Negative lymph node (LN) status (pN0) by LN sampling or LN dissection
• * Unknown pathological LN status is not allowed, except for disease classified as cT ≤ cT1c with baseline PSA ≤ 10 ng/mL, Gleason score \< 7, and ≥ 12 positive core biopsies \< 50%
• * Undetectable post-operative PSA within 3 months of surgery
• PATIENT CHARACTERISTICS:
• WHO performance status 0-1
• WBC ≥ 3 x 10\^9/L
• Hemoglobin ≥ 110 g/L
• Platelet count ≥ 100 x 10\^9/L
• No other malignancy except adequately treated basal cell carcinoma of the skin or other malignancy from which the patient has been disease free for at least 5 years
• No psychological, familial, sociological, or geographical condition potentially hampering compliance with the study protocol and follow-up schedule
• PRIOR CONCURRENT THERAPY:
• See Disease Characteristics
• More than 5 years since prior chemotherapy
• No prior pelvic irradiation
• No prior bilateral orchiectomy
• No prior hormonal treatment except neoadjuvant treatment lasting ≤ 3 months
• No other concurrent anticancer agent or modality