Antioxidant Replacement Therapy in Patients With Alcohol Abuse

Exclusion Criteria

• •Prior medical history of liver disease (documented history of cirrhosis, total bilirubin ≥ 2.0 mg/dL, or albumin \< 3.0)
• •Prior medical history of gastrointestinal bleeding (due to the concern of varices)
• •Prior medical history of heart disease (documentation of ejection fraction \< 50%, myocardial infarction, or severe valvular dysfunction)
• •Prior medical history of renal disease (end-stage renal disease requiring dialysis, or a serum creatinine ≥ 2 mg/dL)
• •Prior medical history of lung disease defined as an abnormal chest radiograph or spirometry (FVC or FEV1\<80%)
• •Concurrent illicit drug use defined as a positive toxicology screen
• •Prior history of diabetes mellitus
• •Prior history of HIV infection
• •Failure of the patient to provide informed consent
• •Refusal of the patient's attending physician to provide consent to participate
• •Pregnancy
• •No prior history of recent acetaminophen use due to the effects of this drug on hepatic glutathione concentrations (96)
• •History of malnutrition as defined as a Nutritional Risk Index of less than 90. This index relies on the serum albumin concentration and the percentage of usual body weight in the following manner; NRI = 100x \[1.59 x albumin (g/l)\] + \[0.417 x (current weight/usual body weight in the past 6 months)\].
• •Homeless population (who do not have transitional housing)