Lead Sponsor

Pfizer

Age

18 - 99 years

Sex

ALL

Healthy Volunteers

No

•Diagnosis of primary open-angle glaucoma or ocular hypertension in one or both eyes
•Intraocular Pressure (IOP) of at least 22 mmHg and not more than 30 mmHg in either eye at 8 AM after discontinuing previous glaucoma treatment
•Visual acuity correctable to 20/100 or better in each eye.

•Closed/barely open anterior chamber angle or a history of acute angle closure in either eye.
•Diagnosis of a clinically significant or progressive retinal disease (eg, diabetic retinopathy, macular degeneration) in either eye.
•Advanced glaucoma or a history of severe central visual field loss in either eye.
•History of ocular surgery or trauma in either eye within 6 months of the screening visit.
•History of ocular infection, ocular inflammation, or laser surgery in either eye within 3 months of the screening visit.