Comparison of Cardiac Computed Tomography and Vasodilator Stress Magnetic Resonance Imaging Perfusion in Patients With Prior Equivocal Stress Test for Detection of Coronary Artery Disease
Saves the questions and what to expect into your notes, next to the visit they belong to.
Keep this study
Lead
National Heart, Lung, and Blood Institute (NHLBI)
Noninvasive cardiac stress testing is imperfect. Inconclusive test results generate further expensive testing. We will do both cardiac computed tomography (CT) and stress cardiac magnetic resonance imaging (MRI) in patients who have an inconclusive noninvasive cardiac stress test. We will test whether MRI predicts significant coronary artery disease in a more cost-effective and accurate manner than CT, or vice versa.
Age
18–100
Sex
ALL
Healthy volunteers
Not accepted
You may be eligible if
18 years of age and older
Prior equivocal stress study within the preceding 90 days
Able to provide informed consent
You may not be if
Decompensated heart failure (unable to lie flat during MRI or CT)
Severe kidney disease (MDRD estimated Glomerular Filtration Rate less than 30mL/min/1.73m(2).
Prior cardiac revascularization with coronary stent or bypass surgery
Resting tachycardia (HR greater than l00 bpm)
Pregnant women (when uncertain, subjects will undergo urine or blood testing)
Lactating women (unless they are willing to discard breast milk for 24 hours after receiving gadolinium)
Second (Type II) and third degree atrioventricular heart block
Asthma or chronic pulmonary disease (emphysema) actively treated with bronchodilators or leukotriene antagonists
Cardiac pacemaker or implantable defibrillator
Cerebral aneurysm clip
Neural stimulator (e.g. TENS-Unit)
Any type of ear implant
Ocular foreign body (e.g. metal shavings)
Any implanted device (e.g. insulin pump, drug infusion device)
