Pioglitazone vs. Placebo in Association With Pegylated Interferon and Ribavirin in HCV Patients With Insulin Resistance

Exclusion Criteria

• •Cardiovascular disease: heart failure stage NYHA II, III or IV, unstable angina, myocardial infarction in the previous year, cardiac surgery or stroke
• •Alcohol consumption exceeding 40 g / day
• •Decompensated liver disease: Child-Pugh B 8 or higher, or one of the following : bilirubin over 35 mol / L, TP below 50%, ascites, encephalopathy
• •Hepatocellular carcinoma or any other neoplasm (except if in remission for \> 5 years)
• •Other documented chronic liver disease
• •Insulin treated diabetes
• •HBV or HIV co-infection infection confirmed
• •Thrombocytopenia below 50 000/mm ³; neutropenia below 750/mm ³ or hemoglobin below 11 g / dL
• •Drug-induced steatosis(tamoxifen, glucocorticosteroids, amiodarone, tetracyclines).
• •Bone marrow or solid organ transplantation
• •Pregnancy or breastfeeding, or desire for pregnancy during the study period.
• •Patients under legal protection or unable to express their consent