Treatment of Resistant Metastatic Melanoma Using Decitabine, Temozolomide and Panobinostat

Most chemotherapeutics target rapidly proliferating cells, leaving quiescent cells and those with extended cell cycles unaffected. The investigators propose that this combination of decitabine, temozolomide, and panobinostat will target both melanoma stem cells and rapidly proliferating melanoma cells. The use of two drugs that regulate gene expression epigenetically (panobinostat and decitabine) in combination with a chemotherapeutic agent (temozolomide) is hypothesized to: * induce expression genes (e.g., Apaf-1) that increase chemosensitivity of tumor cells and enhance apoptosis * potentiate the cytotoxic effect of temozolomide by epigenetic modulation, and * induce proliferation and differentiation of tumor stem cells, thus enabling senescence and apoptosis. Secondary objectives: * To measure overall survival * To measure the time to progression of patients treated with this combination in comparison to patients treated historically with DTIC (the current standard of care). * To evaluate treatment response with FDG PET and compare FDG PET with conventional imaging for treatment response assessment.