Saves the questions and what to expect into your notes, next to the visit they belong to.
Keep this study
Lead
Alberta Health services
The rationale for PCI is that the brain is a sanctuary site where cancer cells can remain inaccessible to chemotheraphy and agents such as trastuzumab due to the blood brain barrier, which prevents potentially harmful chemicals such as chemotherapy agents and antibodies such as trastuzumab from reaching the brain. Decreasing the incidence of brain metastasis with acceptable effects on neurocognitive function would be a significant improvement in the care of patients with MBC.
Age
18–any
Sex
FEMALE
Healthy volunteers
Not accepted
You may be eligible if
Female with HER2-positive disease
18 years of age or older
ECOG greater or equal to 2
Life expectancy greater or equal to 6 months
Able to complete self administered quality of life evaluations and neurocognitive testing
Willing and able to comply with study instructions and commit to all clinic visits for the duration of the study
Women of child-bearing potential must have a negative serum pregnancy test at screening and a negative urine pregnancy test at the baseline visit and must use highly effective birth control during study
Signed informed consent form
You may not be if
Current malignancy in the brain, as determined by screening MRI/CT done no more then 6 weeks prior to study treatment with PCI
Chemo or radiation planned during the period when patients will receive study treatment with PCI
Prior radiotherapy of the brain
Prior stroke or brain hemorrhage in the 6 months prior to screening
History of neurological/psychiatric disorders, including psychotic disorders or demential, or any other reason, which may affect neurocognitive assessment
Inadequate renal function
Other known previous or concomitant serious illness or medical condition that may interfere with participation in the study
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