Diesel Exhaust Particles and Leukotriene Production

Exclusion Criteria

• •1. Pregnancy or breast-feeding. (Pregnancy and the period during breast feeding can affect nasal congestion and be a confounder in this regard.)
• •2. Systemic corticosteroid use within the previous three months or anytime during the challenge protocol.
• •3. Topical nasal corticosteroid use within the past month or anytime during the challenge protocol.
• •4. Systemic antihistamines or decongestant use within past two weeks or anytime during the trial.
• •5. Chronic sinusitis or chronic non-allergic rhinitis.
• •6. Use of reserpine.
• •7. Cigarette smoking within the past year or during the challenge protocol
• •8. Use of topical nasal antihistamines, chromoglycolates (chromolyn, Cromlon®), decongestants or non-steroidal anti-inflammatory agents (NSIADS) within the preceding week or anytime during the challenge protocol.
• •9. Present or treatment within the past 10 years with allergy immunotherapy (injections).
• •10. Present or past treatment with anti-IgE therapy.
• •11. Any unusual exposure to air pollutants (e.g., working as a diesel mechanic) that, in the opinion of the investigators, might compromise the individual's ability to participate in the study.
• •12. Living arrangement where the subject has a cat dwelling within the subject's habitation.
• •13. Any serious heart, lung, neurological or kidney disease that in the opinion of the investigators would impair the individual's ability to participate in the study.
• •14. Use of asthma-required medications.