Kisspeptin Administration in the Adult

You may be eligible if

• A. Healthy Subjects
• All healthy subjects will meet the following criteria:
• normal puberty with respect to onset and pace,
• no chronic diseases,
• no difficulty with blood draws,
• no prescription medications for at least 2 months with the exception of seasonal allergy medications and hormone replacement therapy,
• no illicit drug use or excessive alcohol consumption (\< 10 drinks/week),
• no history of a medication reaction requiring emergency medical care,
• normal physical exam and laboratory studies within protocol reference ranges.
• Additional criteria based on subject population:
• 1. Healthy Men:
• * between 21 and 40 years old,
• * normal erectile and ejaculatory function, no history of reproductive disorders,
• * testicular volume \>15 ml.
• 2. Healthy women:
• * between 21 and 40 years old,
• * not breastfeeding or pregnant,
• * menstrual cycles between 25 and 35 days in duration, at least 11 periods/year, with no more than 5 days variability in cycle duration,
• * no evidence for androgen excess (hirsutism or acne),
• * at screening, negative hCG pregnancy test,
• * negative screening for Factor V Leiden for those who might receive estradiol treatment as a part of this study.
• 3. Healthy postmenopausal women:
• * between 50 and 60 years old,
• * no menstrual periods within the last year,
• * previous history of menstrual cycles between 25 and 35 days in duration, with no more than 5 days variability in cycle duration,
• * if applicable, able to undergo washout from hormone therapy,
• * no evidence for androgen excess (hirsutism or acne),
• * negative screening for Factor V Leiden for those who might receive estradiol treatment as a part of this study.
• B. Subjects with Reproductive Disorders
• All subjects with reproductive disorders will meet the following criteria:
• 18 years or older,
• all medical conditions stable and well controlled,
• no prescription medications known to affect reproductive endocrine function for at least 2 months except for medications used to treat the subject's reproductive condition,
• no history of a medication reaction requiring emergency medical care,
• no illicit drug use or excessive alcohol consumption (\<10 drinks/week),
• for women, not breastfeeding or pregnant,
• if applicable, able to undergo appropriate washout from hormone therapy,
• normal physical exam and laboratory studies within protocol reference ranges,
• for women, at time of screening negative hCG pregnancy test.
• Additional criteria based on subject population:
• 1. Men and women with hypogonadotropic hypogonadism,
• * Confirmed diagnosis by low sex steroids in the setting of low or inappropriately normal gonadotropins,
• * If needed, additional labs and imaging tests may be performed.
• 2. Women with Polycystic Ovarian Syndrome (PCOS)
• * Confirmed diagnosis of PCOS,
• * If needed, additional labs and imaging tests may be performed.
• 3. Men and women with hyperprolactinemia
• * confirmed diagnosis of elevated levels of prolactin measured via blood test,
• * no pituitary adenoma OR a microprolactinoma (\<10 mm). Patients with a macroprolactinoma confirmed on MRI imaging will be excluded,
• * willing to complete a dopamine agonist washout.