Known intolerance to protamine

Known or suspected allergy to the used antifibrinolytic agent

Refusal to receive blood or blood product

Planned surgery including the aortic arch and/or descending aorta

Planned surgery including any implantable ventricular assist device

Adult congenital heart diseases

Two or more previous cardiac surgery procedures

Any known autoimmune diseases: Collagen vascular disease (Systemic lupus erythematosus, Rheumatoid arthritis, Sjögrens syndrome) - Endocrine: hyperthyroidism (Graves disease), adrenal insufficiency, Hashimoto's thyroiditis - Neurologic: Multiple sclerosis, myasthenia gravis - Skin: pemphigous vulgaris Hematologic: Pernicious anaemia, Autoimmune haemolytic anaemia - Vasculitis - Primary or secondary antiphospholipid syndrome

Weight above 140 kg

Multi-national Study Investigating the Effect and Safety of rFXIII on Transfusion Needs in Patients Undergoing Heart Surgery

What this study is about