Advancing Niacin by Inhibiting Flushing (ANTI-FLUSH)

Exclusion Criteria

• •1. Contra-indications or known intolerance to the study medications.
• •2. History of congestive heart failure, carcinoid, rosacea, renal failure (GFR\<60 ml/min/m2).
• •3. Active liver disease.
• •4. Active diabetes (defined as any history of type 1 diabetes, or history of type 2 diabetes plus one or more of the following: fasting glucose\>= 126mg/dL at screening or use of anti-diabetic medications within 12 months, or glucose\>200mg/dL 2 hours after a 75 g oral glucose challenge within 12 months.
• •5. History of major surgery within the past 6 weeks, or anticipated major surgery during the course of the study, or any history of organ transplant.
• •6. History of drug abuse within the past 3 years, or regular alcohol use of greater than 14 drinks per week.
• •7. Women who are pregnant, plan to conceive or lactate.
• •8. Peri-menopausal women or women currently experiencing flushing.
• •9. Currently taking vasoactive medications, anti-hypertensives, anti-histamines, Selective Serotonin Re-uptake Inhibitors (SSRIs), NSAIDS, oral steroids, leukotriene inhibitors, supplemental quercetin and \> 50mg niacin.