Evaluating the Role of the Addition of Ovarian Function Suppression (OFS) to Tamoxifen in Young Women

Inclusion Criteria

• •1. Patients must have undergone excision of the primary breast mass, proven histologically to be invasive breast adenocarcinoma.
• •2. Patients must be within 3 months after the last cycle of chemotherapy.
• •3. Patients must have the history of normal menstruation prior to the start of chemotherapy.
• •4. Stage I, II or III
• •5. Woman, less than or equal to 45 years of age
• •6. Hormone receptor status : ER+ve and/or PgR+ve
• •7. WHO performance status 0, 1 or 2.
• •8. Patients who were treated with cytotoxic chemotherapy in pre- or post- surgery.
• •9. Adequate haematological function defined by haemoglobin 10g/dL, neutrophil count 1.5x109/L and platelets 100x109/L.
• •10. Adequate hepatic function defined by AST and ALT 2.5xupper limit of normal. Alkaline phosphatase 5xupper limit of normal, unless bone metastases in the absence of liver disease. Renal function adequate defined by creatinine\<175mmol/L.