The Pharmacokinetics of Dexmedetomidine in Children

Inclusion Criteria

• •Age 3 - 11.9 years
• •* 2 age groups: 3.0 - 5.9 years, 6.0 - 11.9 years
• •Patients will be equally distributed within each age group
• •Meets criteria to receive dexmedetomidine sedation for MRI:
• •* Active, uncontrolled gastroesophageal reflux - an aspiration risk
• •* Active, uncontrolled vomiting - an aspiration risk
• •* Current (or within past 3 months) history of apnea requiring an apnea monitor
• •* Active, current respiratory issues that are different from the baseline status (pneumonia,exacerbation of asthma, bronchiolitis, respiratory syncytial virus)
• •* Unstable cardiac status (life threatening arrhythmias, abnormal cardiac anatomy,significant cardiac dysfunction)
• •* Craniofacial anomaly, which could make it difficult to effectively establish a mask airway for positive pressure ventilation if needed
• •* Current use of digoxin
• •* Moya Moya Disease
• •* New-onset stroke
• •* Provide written consent to take part in the research study