Computed Tomography (CT) Perfusion Imaging of Lung Cancer

Drug/Device Information 1\) Contrast 30 cc bolus of a low osmolar, iodinated CT contrast agent, which is FDA approved and used in the clinical CT Imaging procedure. 2\) Scanner The 64 row-multidetector row CT unit (LightSpeed VCT, GE Healthcare, Milwaukee, WI) is FDA approved for clinical CT imaging Research Design and Methods 1\) Primary Endpoint 1\. Diagnostic yield of tumor perfusion measurements using a contrast assisted computed tomography technique. 2\) Secondary Endpoints 1. Reproducibility of tumor blood flow estimates derived by CT. 2. Assessment of the association between tumor vascularity responses after two cycles of chemotherapy and subsequent best tumor response according to standard anatomic response evaluation criteria (RECIST). 3. Predictive value of tumor blood flow for patient survival, compared to the predictive power of tumor size determinations.