Age

18–any

Sex

ALL

Healthy volunteers

Not accepted

Locally advanced or metastatic colo-rectal cancer
Age \> or = 18 years old
PS-WHO \< or = 2
Polynuclear neutrophil leukocytes \> or = 1500/mm3, platelets \> or = 100000/mm3
Total bilirubin \< or = 3 ULN, ASAT-ALAT \< or = 2.5 ULN
Effective contraception
Written informed consent signed

Xeloda or UFT (Tegafur-uracil) With Folinic Acid in Advanced or Metastatic Colorectal Cancer