OBJECTIVES:
* To complete characterization of metabolic serotypes based on the metabolome, and to adapt these profiles for human epidemiological studies.
* To determine the extent to which metabolic profiles that are reflective of or independent of long-term caloric intake predict breast cancer risk in nested case-control studies.
* To identify critical serum metabolites.
OUTLINE: Laboratory studies, including metabolome profiling by high performance liquid chromatography; and small molecule identification by mass spectroscopy, are performed on previously collected blood samples.
