SWOG-9245 Collecting and Storing Tissue Samples From Patients With Relapsed or Recurrent Non-Hodgkin Lymphoma After Treatment on a Southwest Oncology Group Clinical Trial

RATIONALE: Collecting and storing samples of tissue from patients with non-Hodgkin lymphoma to study in the laboratory may help the study of cancer in the future. PURPOSE: This laboratory study is collecting and storing tissue samples from patients with relapsed or recurrent non-Hodgkin lymphoma after treatment on a Southwest Oncology Group (SWOG) clinical trial.

OBJECTIVES: * Acquire fresh snap-frozen lymphoma tissue from patients with relapsed or recurrent non-Hodgkin lymphoma after treatment on a Southwest Oncology Group (SWOG) clinical trial. * Establish a standard set of procedures for routine acquisition, banking, and study of lymphoma tissues within the SWOG. * Use repository tissue to establish clinical correlations via presently activated phenotyping studies and future projected molecular studies assessing specimen DNA and RNA status. * Examine the biology of therapy failure in relationship to changes in pretreatment and post-treatment immunophenotypic data. OUTLINE: This is a multicenter study. Tissues collected at biopsy are snap-frozen and archived for future molecular and genetic studies. PROJECTED ACCRUAL: Not specified