OBJECTIVES:
* Acquire fresh snap-frozen lymphoma tissue from patients with relapsed or recurrent non-Hodgkin lymphoma after treatment on a Southwest Oncology Group (SWOG) clinical trial.
* Establish a standard set of procedures for routine acquisition, banking, and study of lymphoma tissues within the SWOG.
* Use repository tissue to establish clinical correlations via presently activated phenotyping studies and future projected molecular studies assessing specimen DNA and RNA status.
* Examine the biology of therapy failure in relationship to changes in pretreatment and post-treatment immunophenotypic data.
OUTLINE: This is a multicenter study.
Tissues collected at biopsy are snap-frozen and archived for future molecular and genetic studies.
PROJECTED ACCRUAL: Not specified
