Study of Blood Samples From Older Patients at High Risk of Developing Prostate Cancer and From Healthy Male Participants

You may be eligible if

• DISEASE CHARACTERISTICS:
• Meets 1 of the following criteria:
• * Patient at high risk for developing prostate cancer, due to 1 of the following risk factors:
• * Histologically confirmed proliferative inflammatory atrophy and/or high-grade prostatic intraepithelial neoplasia lesions accompanied by chronic intraprostatic inflammation
• * Abnormality observed during digital rectal exam or transrectal ultrasonography
• * Continued elevated age-adjusted prostate-specific antigen (PSA) meeting at least 1 of the following criteria:
• * Screening PSA \> 4.0 ng/mL
• * Free PSA \< 18%
• * PSA velocity \> 0.75 ng/mL within the past year
• * Healthy volunteer meeting the following criteria:
• * Age-matched
• * Normal PSA level (≤ 2.1 ng/mL)
• * Normal digital rectal exam
• * No prostatitis or benign prostate hyperplasia
• * No urinary symptoms (diagnosed or undiagnosed)
• No diagnosis of cancer
• PATIENT CHARACTERISTICS:
• Patients and healthy controls:
• No chronic inflammatory conditions, especially those for which regular use of non-steroidal anti-inflammatory medications (NSAIDs) is prescribed/recommended, including any of the following:
• * Coronary heart disease
• * Chronic obstructive pulmonary disease (COPD)
• * Psoriasis
• * Pelvic inflammatory disease
• * Multiple sclerosis
• * Arthritis
• * Lupus
• * Hashimoto thyroiditis
• * Inflammatory bowel disease (i.e., ulcerative colitis or Crohn disease)
• PRIOR CONCURRENT THERAPY:
• No prior radiotherapy or surgery to the prostate (healthy controls)