Clareo Health | Inflammation in Chronic Kidney Disease and Cardiovascular Disease - The Role of Genetics and Interleukin-1 Receptor Antagonist (IL-1ra)
Saves the questions and what to expect into your notes, next to the visit they belong to.
Keep this study
Lead
VA Office of Research and Development
Age
18–any
Sex
ALL
Healthy volunteers
Not accepted
You may be eligible if
18 years of age or older;
estimated glomerular filtration rate (eGFR) between 15-60 mL/min/1.73m2;
Must be on stable regimens of medications that can affect inflammatory axis (Aspirin, Thiazolidinediones, statins);
Willing and able to comply with clinic visits and study-related procedures;
Provide signed informed consent.
You may not be if
Recent infection or hospitalization (within one month);
History of active or chronic hepatitis B, history of active or chronic hepatitis C, human immunodeficiency virus (HIV), history of tuberculosis (patient must be purified protein derivate negative);
high sensitivity c-reactive protein (hsCRP) \<2mg/L or \>30 mg/L;
Body mass index (BMI) \> 40;
Known diagnosis of severe congestive heart failure with documented ejection fraction (EF) \< 35%;
Pregnant or breast-feeding women;
Sexually active men\* or women of childbearing potential\*\* who are unwilling to practice adequate contraception during the study (adequate contraceptive measures include stable use of oral contraceptives or other prescription pharmaceutical contraceptives for 2 or more menstrual cycles prior to screening; intrauterine device (IUD); bilateral tubal ligation; vasectomy; condom plus contraceptive sponge, foam, or jelly, or diaphragm plus contraceptive sponge, foam, or jelly).
* Contraception is not required for men with documented vasectomy. \*\*Postmenopausal women must be amenorrheic for at least 12 months in order not to be considered of child bearing potential. Pregnancy testing and contraception are not required for women with documented hysterectomy or tubal ligation.
