Effect of Exendin-(9-39) on Fasting Adaptation and Protein Sensitivity

Exclusion Criteria

• •Current therapy with medications that may affect glucose metabolism such as octreotide, diazoxide, high dose glucocorticoids, adrenergic agents, etc. Subjects will be eligible to participate if the last dose of octreotide is given 48 hrs before study day 1 and the last dose of diazoxide is given 72 hours before study day 1
• •Evidence of a medical condition that might alter results or compromised the elimination of the peptide, including active infection, kidney failure, severe liver dysfunction, severe respiratory or cardiac failure
• •Pregnancy
• •Subjects with milk protein allergy will be excluded for participating in studies involving protein tolerance test