OBJECTIVES:
* Provide cancer investigators access to a wide variety of tissues and biospecimens for translational studies in cancer.
* Collect and preserve tissue from the primary organ site (uninvolved and involved with cancer), from the metastases, from patient blood (serum and lymphocytes), and from patient urine.
* Provide quality-controlled storage and management of the specimen bank.
* Collect relevant clinical and pathologic information with appropriate privacy protection.
* Contribute to the development of a comprehensive database annotated with relevant clinical data, pathology, and research findings.
OUTLINE: This is a multicenter study.
Tumor samples, lymph node samples, and normal pancreas tissue samples are collected. Blood samples are also collected prior to surgery, six months after the initial blood draw and tissue sample collection, and every six months thereafter for two years.