Have had more than two relapses

Have had radiosurgery

Have a cardiac ejection fraction \< 50% by MUGA or ECHO

Have Troponin-I elevated above the normal range

Have an increasing steroid requirement

Have MRI evidence at baseline of enlarging or clinically significant intratumor hemorrhage

Have active stroke and/or transient ischemic attack not optimally managed

Have active cardiovascular disease (e.g. sub-optimally managed angina, impending myocardial infarction, or uncontrolled hypertension)

Be pregnant or breast feeding

Have had prior hypersensitivity reaction to Cremophor EL

Be HIV positive

Phase 2 Study MPC-6827 for Recurrent Glioblastoma Multiforme