Efficacy and Safety Study of Budesonide to Treat Oral Chronic Graft vs Host Disease (cGvHD)

Exclusion Criteria

• •Uncertain diagnosis of resistant oral cGvHD
• •Symptomatic oral cGvHD of hyperkeratotic type solely
• •Current active oral bacterial, viral, or fungal infection
• •Unwilling to forego concurrent treatment for mucosal lesions and/or related oral pain
• •Requiring addition of new systemic therapy including steroids, or radiation therapy
• •Local intestinal infection
• •Abnormal hepatic function or liver cirrhosis
• •If careful medical monitoring is not ensured: tuberculosis, cardiovascular disease, diabetes mellitus, osteoporosis, active peptic ulcer disease, glaucoma, cataract, infection
• •Second line treatment of oral cGvHD with topical steroids