Need for hemodialysis, peritoneal dialysis, or transplantation at the time of enrollment or projected to start within 6 months after enrollment

Low functional capacity including inability to walk a flight of stairs with a bag of groceries (NYHA Class III/IV Heart Failure)

Prior erythropoietic agents within last 12 weeks

TSAT \< 15% and not receiving the recommended dose for iron deficiency

Uncontrolled hypertension defined as greater than 180 mm Hg systolic or 110 mm Hg diastolic

Potentially "brittle" diabetes with the propensity for symptomatic hypoglycemia after a 6 hour fast

New diagnosis or ongoing therapy for Cancer

Pregnancy

Myocardial Glucose Uptake (MGU) in Patients With Chronic Kidney Disease