Saves the questions and what to expect into your notes, next to the visit they belong to.
Keep this study
Lead
R-Pharm
Age
18–any
Sex
FEMALE
Healthy volunteers
Not accepted
You may be eligible if
Women aged 18 years and older
Histologic or cytologic diagnosis of endometrial carcinoma
Evidence that the cancer is advanced, recurrent, or metastatic and not curable by local measures, such as surgery or radiation.
Karnofsky performance status \>=70
Measurable or nonmeasurable disease that has progressed since last treatment.
* If only disease is confined to a solitary lesion, its neoplastic nature must be confirmed by histology or cytology.
* Disease in a previously irradiated field is acceptable as the only site of measurable disease only if there has been clear progression since completion of radiotherapy.
All therapy directed at endometrial cancer must be discontinued 21 days prior to start of treatment, except for hormonal therapy which must be discontinued at least 1 week prior to start of study treatment. Concurrent administration of hormone replacement therapy is allowed.
Prior therapy: Participants must have failed 1 prior platinum-based chemotherapeutic regimen for endometrial cancer. May have received 2 prior chemotherapy regimens if 1 regimen was given for stage I or II disease. May have received any number of prior non-cytotoxic regimens such as monoclonal antibodies, cytokines, signal transduction inhibitors, or hormonal therapy. Previous radiation therapy is allowed.
You may not be if
Carcinosarcoma (malignant mixed mullerian tumor)
Endometrial leiomyosarcoma and endometrial stromal sarcomas
Participants who received no prior chemotherapy for endometrial cancer or ≥2 prior chemotherapy regimens (exceptions defined in protocol)
Known brain metastases
Receipt of prior ixabepilone therapy
Concurrent active infection requiring antibiotics or other therapy
Concurrent unstable disease or other debilitating illness, such as congestive heart failure, unstable angina, myocardial infarction, or other cardiac disease that could jeopardize participation, within the last 6 months
For participants whose prior therapy did not include an anthracycline and therefore may be randomized to doxorubicin, left ventricular ejection fraction \<50% as measured by multigated radionuclide angiography or echocardiography
History of malignancy, except nonmelanoma skin cancer, carcinoma in situ of the cervix, or carcinoma in situ of the breast, within the last 5 years that has not been treated with chemotherapy
Known human immunodeficiency viral infection
Psychiatric disorders or other conditions rendering the participant incapable of complying with protocol requirements
Absolute neutrophil count \<1500/mm\^3
Platelets \<100,000/mm\^3
Hemoglobin \<9 g/dL
Total bilirubin \>1.5\*upper limit of normal (ULN), except for those with Gilbert's disease
Aspartate aminotransferase or alanine aminotransferase \>2.5\*ULN
Serum creatinine \>1.5\*ULN
Grade ≥2 neuropathy (sensory or motor)
No concurrent therapy (chemotherapy, hormonal, or investigational) directed at endometrial cancer during the study
Clareo Health | A Study of Ixabepilone as Second-line Therapy for Locally Advanced, Recurrent, or Metastatic Endometrial Cancer
