Long-Term Administration Study of Aripiprazole as an Adjunctive Therapy in Patients With Major Depressive Disorder

Exclusion Criteria

• •1. Female patients of child bearing potential who wish to become pregnant during the treatment period, or within 4 weeks after study completion/discontinuation
• •2. Female patients who are pregnant, possibly pregnant, or breast feeding
• •3. Patients judged to be unable to tolerate any type of antidepressant treatment (including drugs not being used in the current episode of major depressive disorder), based on treatment history to date
• •4. Patients who have previously received electro-convulsive therapy
• •5. Patients who have participated in clinical studies on medical devices or other drugs within the past month
• •6. Patients at risk of having serious adverse events or developing symptoms that could interfere with safety and efficacy evaluations (such as symptoms of fibromyalgia syndrome overlapping with symptoms of depression), based on previous medical history
• •7. Patients with a history or a complication of diabetes
• •8. Patients with thyroid disease (excluding patients who are stabilized on drug therapy for at least 3 months)
• •9. Patients with a history of serotonin syndrome or psychotropic neuroleptic malignant syndrome
• •10. Patients with a history of seizure disorder (epilepsy etc.)