Dose Escalation Trial to Evaluate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Intravenous ALN-VSP02 In Patients With Advanced Solid Tumors With Liver Involvement

Inclusion Criteria

• •Patients must have histologically or cytologically confirmed advanced solid tumors that have recurred or progressed following standard therapy, or that have not responded to standard therapy, or for which there is no standard therapy, or who are not candidates for standard therapy
• •Patient has measurable tumor in the liver
• •At least 28 days have elapsed since the patient's prior systemic therapy, radiotherapy, or any major surgery
• •Patient has an Eastern Cooperative Oncology Group (ECOG) performance status score of 0-1
• •Patient has adequate hematologic, liver, and renal function
• •Patient is seronegative for hepatitis B virus (HBV) and hepatitis C virus (HCV)
• •Patient has a life expectancy \> 12 weeks