Repeat Dose Safety Study for Compound to Treat Hematologic Cancer

Exclusion Criteria

• •1. Chemotherapy, radiotherapy, or immunotherapy within 28 days (or 42 days for prior nitrosoureas or mitomycin C) prior to the first dose of study drug.
• •2. Use of an investigational anti-cancer drug within 28 days or five half-lives, whichever is longer, preceding the first dose of study drug.
• •3. Current use of a prohibited medication or requires any of these medications during treatment with study drug.
• •4. Current use of anticoagulants at therapeutic levels within seven days prior to the first dose of study drug, including warfarin, low molecular weight heparin and direct thrombin inhibitors. Low dose (prophylactic) anticoagulants are permitted provided that subject's PT and PTT meet entry criteria.
• •5. Current use of any anti-platelet agent (e.g. dipyridamole, clopidogrel) other than aspirin (81 mg daily).
• •6. Presence of active gastrointestinal disease or other condition that could affect gastrointestinal absorption (e.g. malabsorption syndrome) or predispose subject to gastrointestinal ulceration.
• •7. Any major surgery within the last four weeks.
• •8. Unresolved toxicity (except alopecia) Grade 2 from previous anti-cancer therapy unless agreed to by a Medical Monitor and the Investigator
• •9. Previously diagnosed diabetes mellitus (Type 1 or 2).
• •10. Current use of oral corticosteroids, with the exception of inhaled or topical corticosteroids.
• •11. Any serious or unstable pre-existing medical, psychiatric, or other condition (including lab abnormalities) that could interfere with subject safety or with obtaining informed consent.
• •12. Symptomatic or untreated central nervous system (CNS) involvement by the hematologic malignancy (including primary CNS lymphoma).
• •13. Evidence of severe or uncontrolled systemic diseases
• •14. Known infection with HIV, HBV or HCV.
• •15. QTc interval ≥ 470 msecs.
• •16. Other clinically significant ECG abnormalities including 2nd degree (Type II) or 3rd degree atrioventricular (AV) block.
• •17. History of myocardial infarction, acute coronary syndromes (including unstable angina), coronary angioplasty, or stenting or bypass grafting within the past six months.
• •18. Class III or IV heart failure as defined by the New York Heart Association (NYHA) functional classification system.
• •19. Pregnant or lactating female.
• •20. Active drug or alcohol abuse.
• •21. History of sensitivity to heparin or heparin-induced thrombocytopenia.