Blood Gene Expression Signature in Patients Diagnosed With Probable Alzheimer's Disease Compared to Patients Suffering From Other Types of Dementia

1. AD group :

* Any pathology, medical condition or symptoms that may lead to reconsider the initial diagnosis of probable AD, or that may rend the initial diagnosis of probable AD doubtful at entry, according to the opinion of the investigator.

* Current or recent history of drug or alcohol abuse or dependence.

* Diagnostic of Mild Cognitive Impairment defined by subjective complaints from the patient regarding memory and/or cognitive symptoms, objective memory and/or cognitive impairment at testing but not meeting AD diagnostic criteria, and not affecting daily living activities.

* Current diagnosis of brain tumour.

* Any current pathology or medical condition, for which blood sampling may involve a risk for the patient's health, according to the opinion of the investigator.

* Pregnancy.

* Patient who is not registered at "Sécurité Sociale".

* Current participation in another study using an investigational non-marketed product.

2. Non-AD demented group :

* Any pathology, medical condition or symptoms that may lead to reconsider the initial diagnosis of dementia the patient is suffering from, or that may rend the initial diagnosis of dementia doubtful at entry, according to the opinion of the investigator.

* Diagnostic of Mild Cognitive Impairment defined by subjective complaints from the patient regarding memory and/or cognitive symptoms, objective memory and/or cognitive impairment at testing but not meeting the diagnostic criteria for dementia, and not affecting daily living activities.

* Current diagnosis of brain tumour.

* Any current pathology or medical condition for which blood sampling may involve a risk for the patient's health, according to the opinion of the investigator.

* Current or recent history of drug or alcohol abuse or dependence.

* Pregnancy.

* Patient who is not registered at "Sécurité Sociale".

* Current participation in another study using an investigational non-marketed product.

3. Cognitive impairment-free control group :

* Subject spontaneously complaining from significant cognitive impairment.

* Known family history of dementia.

* Diagnosis of any type of dementia (either AD or non-AD dementia), Mild Cognitive Impairment, or any current or past history of CNS pathology (including but not limited to brain injury, brain tumour, stroke, normal pressure hydrocephalus, Parkinson's disease, epilepsy, multiple sclerosis,…) that may be responsible for the occurrence of dementia.

* History or current clinically significant psychiatric pathology (including but not limited to psychotic disorders, bipolar disorder, personality disorders).

* Current major depressive disorder, either treated or not, associated with clinically significant symptoms.

* Any current pathology or medical condition for which blood sampling may involve a risk for the subject's health, according to the opinion of the investigator.

* Current or recent history (within one month) of clinically significant pathology, medical condition (including hospitalization) or symptoms. However, chronic diseases or medical conditions which are considered stable are accepted, provided that they are compatible with other study selection criteria.

* Current or recent history of drug or alcohol abuse or dependence.

* Subject who is not registered at "Sécurité Sociale".

* Current participation in another study using an investigational non-marketed product.

Blood Gene Expression Signature in Patients Diagnosed With Probable Alzheimer's Disease Compared to Patients Suffering From Other Types of Dementia

What this study is about

Blood Gene Expression Signature in Patients Diagnosed With Probable Alzheimer's Disease Compared to Patients Suffering From Other Types of Dementia

What this study is about