A Study of GDC-0941 in Participants With Locally Advanced or Metastatic Solid Tumors for Which Standard Therapy Either Does Not Exist or Has Proven Ineffective or Intolerable

Exclusion Criteria

• •Leptomeningeal disease as the only manifestation of the current malignancy
• •History of Type 1 or 2 diabetes mellitus requiring regular medication
• •Any condition requiring anticoagulants, such as warfarin, heparin, or thrombolytics
• •Malabsorption syndrome or other condition that would interfere with enteral absorption
• •Known untreated central nervous system (CNS) malignancies or treated brain metastases that are not radiographically stable for \>/=3 months
• •Active congestive heart failure or ventricular arrhythmia requiring medication
• •Uncontrolled ascites requiring weekly large-volume paracentesis for 3 consecutive weeks prior to enrollment
• •Active infection requiring intravenous (IV) antibiotics
• •Requirement for any daily supplemental oxygen
• •Uncontrolled hypomagnesemia or hypokalemia, defined as values below the lower limit of normal (LLN), or hypercalcemia above the upper limit of normal (ULN) for the institution despite adequate electrolyte supplementation or management
• •Clinically significant history of liver disease, including viral or other hepatitis, current alcohol abuse, or cirrhosis
• •Known human immunodeficiency virus (HIV) infection
• •Any other diseases, active or uncontrolled pulmonary dysfunction, metabolic dysfunction, physical examination finding, or clinical laboratory finding giving reasonable suspicion of a disease or condition that contraindicates the use of an investigational drug or that may affect the interpretation of the results or renders the participant at high risk from treatment complications
• •Significant traumatic injury within 3 weeks before Day 1
• •Major surgical procedure within 4 weeks prior to initiation of study treatment
• •Treatment with chemotherapy, hormonal therapy (except gonadotropin releasing hormone \[GnRH\] agonists or antagonists for prostate cancer), immunotherapy, biologic therapy, or radiation therapy (except palliative radiation to bony metastases) as cancer therapy within 4 weeks prior to initiation of study treatment
• •Palliative radiation to bony metastases within 2 weeks prior to initiation of study treatment
• •Need for chronic corticosteroid therapy for greater than (\>) 7 days