Saves the questions and what to expect into your notes, next to the visit they belong to.
Keep this study
Lead
Kansas City Veteran Affairs Medical Center
With
Sanofi
Age
18–any
Sex
MALE
Healthy volunteers
Not accepted
You may be eligible if
Patients must have histologically proven adenocarcinoma of the prostate.
Patients must meet at least one of the following high risk criteria:
* PSA \> 20
* Gleason score 8 or greater
* Presence of pathological Gleason grade 4 or higher as the majority sum on biopsy core
* Greater than 50% of cores at time of biopsy positive for cancer
* Clinical Stage T3 Disease
* Patients must have PS of 0-1(ECOG) and medically deemed a surgical candidate for radical prostatectomy.
* Age \> or = to 18.
* Patients with a pre-existing peripheral neuropathy of equal to or greater than grade two are ineligible.
* Serum Creatinine must be \< or equal to 2.0mg/dl.
* Patients must currently not receiving any drug which is metabolized by cytochrome P450-3A4 including the statins, cyclosporin, terfenadine and erythromycin.
* Prior to receiving any dose of docetaxel, patients should have absolute neutrophil counts \> 1,500, hemoglobin \> 8.0 g/dl and platelet counts \> 100,000/mm3.
You may not be if
* Patients receiving concurrent warfarin are eligible but require monitoring of protime on a weekly basis.
* Patients must not had have received prior treatment with surgery, radiation or hormone deprivation.
* Patients must not have had a history of peptic ulcer disease requiring treatment with surgery or endoscleral.
* All patients must sign informed consent.
* Men of childbearing potential must be willing to consent to using effective contraception while on treatment and for at least 3 months thereafter.
