Riluzole in Treating Patients With Stage III or Stage IV Melanoma That Cannot Be Removed by Surgery

You may be eligible if

• DISEASE CHARACTERISTICS:
• Histologically confirmed malignant melanoma
• * Unresectable stage III or stage IV disease
• Measurable disease according to RECIST criteria, defined as ≥ 1 unidimensionally measurable lesion \> 20 mm by conventional techniques or \> 10 mm by spiral CT scan
• No known brain metastases unless treated and stable for ≥ 2 weeks by MRI evaluation
• PATIENT CHARACTERISTICS:
• ECOG performance status 0-2
• ANC ≥ 1,000/μL
• Platelet count ≥ 50,000/μL
• Total bilirubin ≤ 2 times upper limit of normal (ULN)
• AST/ALT ≤ 3 times ULN
• INR ≤ 1.5 times ULN
• Not pregnant
• Negative pregnancy test
• Fertile patients must use effective contraception during and for 2 weeks after completion of study treatment
• No second primary malignancy, except carcinoma in situ of the cervix, adequately treated nonmelanoma carcinoma of the skin, or other malignancy treated ≥ 5 years ago with no evidence of recurrence
• No concurrent serious systemic disorders (including active infections) that, in the opinion of the investigator, would compromise the safety of the patient or compromise the patient's ability to complete the study
• No history of allergic reactions attributed to riluzole
• No known history of hepatitis B or C
• PRIOR CONCURRENT THERAPY:
• No more than 1 prior therapeutic chemotherapy regimen for advanced melanoma
• Prior treatment with riluzole on clinical trial CINJ-090603 allowed
• No other concurrent investigational or commercial agents or therapies for the treatment of the malignancy