Effects of a Western-type Diet on Colorectal Inflammation

Exclusion Criteria

• •Personal history of cancer other than non-melanoma skin cancer within the past 10 years
• •History of hereditary non-polyposis colon cancer
• •Intestinal malabsorption, inflammatory bowel disease
• •Prior gastrointestinal surgery other than appendectomy or surgery of the esophagus
• •Any excess bleeding or coagulation disorders
• •Subjects taking anti-coagulants, sterol-binding resins, NSAIDs other than aspirin, \< 600mg per day, other study medications, or other multiple medications that might, in the view of the study physicians, alter colonic function or inflammation
• •Total cholesterol greater than 240mg/dl, triglycerides \> 600mg, LDL-C \> 175
• •Subjects with a history of coronary artery disease
• •HIV positive subjects
• •Subjects taking antibiotics, anti-diabetes, hormone replacement therapy, oral, transplanted or injected contraceptives (thyroid hormone therapy is permitted as long as the subject is euthyroid)
• •Currently participating in other clinical studies or completed participation in other clinical studies within the last 30 days