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Lead
University of Colorado, Denver
The sudy will compare rates and duration of postoperative delirium in groups that receive L-tryptophan supplementation compared to placebo.
Age
60–any
Sex
ALL
Healthy volunteers
Not accepted
You may be eligible if
Included subjects will be 60 years and older undergoing an operation with a planned ICU admission post-operatively.
You may not be if
Medications that, when combined with tryptophan, increase the risk of serotonin syndrome. The classes of medications include:
* monoamine oxidase inhibitors
* selective serotonin reuptake inhibitors
* serotonin-norepinephrine reuptake inhibitors
* triptans
* opioids
* central nervous system stimulants
* bupropion
* St. John's Wort
Patients who undergo an operation on their brain.
Factors which prevent delirium assessment with the CAM-ICU: vision impairment or non-fluent English speakers.
A lowered seizure threshold including:
* history of seizure disorder
* alcohol abuse defined by a high AUDIT score (\>8 females and \>13 males)
* benzodiazepine or barbiturate abuse within three months of the study
* OR a positive urine toxicology screen for alcohol, benzodiazepines or barbiturates.
Significant liver disease (Child's class B or greater) or significant renal disease (Creatinine ≥2.0).
History of Huntington's or Addison's disease. (As requested by the FDA)
History of bipolar disorder or a psychotic disorder (such as a psychotic major depression, schizophrenia, schizoaffective disorder, or psychosis in Alzheimer's disease or other dementia). (As requested by the FDA)
Women who are not post-menopausal. (As requested by the FDA)
Clareo Health | A Placebo Controlled Trial Of L-Tryptophan In Post-Operative Delirium
