Renal Osteodystrophy: A Fresh Approach

Exclusion Criteria

• •Pregnancy;
• •Systemic illnesses or organ diseases that may affect bone (except type 1 or type 2 diabetes mellitus);
• •Clinical condition that may limit study participation (e.g., unstable angina, respiratory distress, infections).
• •Chronic alcoholism and/or drug addiction;
• •Participation in a study of an investigational drug during the past 90 days;
• •Allergy to tetracycline.
• •Planning to move out of the area within 2 years of the study;
• •On active transplant list;
• •Treatment within last 6 months with drugs that may affect bone metabolism (except for treatment with calcitriol, vitamin D analogs and/or calcimimetics).
• •Calcidiol level below the normal range. The current routine clinical practice in our dialysis clinics is to check calcidiol status twice yearly and supplement with vitamin D according to serum calcidiol levels. It is therefore unlikely that a substantial number of patients will be excluded due to this exclusion criterion.