First Line Hepato Cellular Carcinoma (HCC)

Exclusion Criteria

• •Child-Pugh Class A
• •ECOG performance status 0-1
• •Adequate hematologic, hepatic, and renal function
• •Prior use of any systemic anti-cancer chemotherapy, immunotherapy or molecular targeted agents for HCC
• •History of active cardiac disease
• •Thrombotic or embolic events within the past 6 months (except HCC tumor thrombus)
• •Any other hemorrhage/bleeding event \>= CTCAE Grade 3 within 8 weeks except for esophageal or gastric varices
• •Inability to swallow tablets or untreated malabsorption syndrome